2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N12442
    Sarmenoside III 947409-91-8 98%
    Sarmenoside III is a flavonol glycoside with hepatoprotective activity isolated from Sedum sarmentosum.
    Sarmenoside III
  • HY-N12529
    13,14-EDT 504435-14-7 98%
    13,14-EDT is a metabolite of oxylipids and adrenal acid that is formed through the cytochrome P450 (CYP) pathway.
    13,14-EDT
  • HY-N12530
    16,17-EDT 351533-79-4 98%
    16,17-EDT is an oxylipin and a metabolite of adrenic acid formed by the cytochrome P450 (CYP) pathway.
    16,17-EDT
  • HY-N12621
    Antifungal agent 91 98%
    Antifungal agent 91(compound 1) is a dihydroflavonol that can be isolated from the leaves of Artocarpus elasticus. Antifungal agent 91 is a PTP1B inhibitor with an IC50 value of 0.17 μM. Antifungal agent 91 has antifungal activity.
    Antifungal agent 91
  • HY-N12650
    Kaempferol 3-O-alpha-L-(2, 3-di-Z-p-coumaroyl) rhamnoside 1197343-21-7 98%
    Kaempferol 3-O-alpha-L-(2, 3-di-Z-p-coumaroyl) rhamnoside (compound 42) is a flavonol that can be isolated from Platanus Occidentalis. Kaempferol 3-O-alpha-L-(2, 3-di-Z-p-coumaroyl) rhamnoside is an inhibitor of alpha-amylase and DPP IV.
    Kaempferol 3-O-alpha-L-(2, 3-di-Z-p-coumaroyl) rhamnoside
  • HY-N12653
    Exserohilone 99572-22-2 98%
    Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts.
    Exserohilone
  • HY-N12664
    α-Glucosidase-IN-54 174284-54-9 98%
    α-Glucosidase-IN-54 (compound 2) is a α-glucosidase inhibitor with the IC50 of 0.011 mM, and can be isolated form Syzygium jambos (L.). α-Glucosidase-IN-54 can be used for study of diabetes.
    α-Glucosidase-IN-54
  • HY-N12688
    2,3-Dihydrocalodenin B 98%
    2,3-Dihydrocalodenin B (Compound 6) is a compound that can be isolated from Knema globularia. 2,3-Dihydrocalodenin B is a potent and non-competitive inhibitor against α-glucosidase and α-amylase, with IC50 values of 1.1 and 2.6 μM, respectively. 2,3-Dihydrocalodenin B can be used for the research of diabetes.
    2,3-Dihydrocalodenin B
  • HY-N12689
    α-Glucosidase-IN-56 26788-86-3 98%
    α-Glucosidase-IN-56 (compound 1) is an orally active, potent α‐glucosidase inhibitor with an IC50 value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities.
    α-Glucosidase-IN-56
  • HY-N12744
    2-O-trans-p-Coumaroylalphitolic acid 67911-63-1 98%
    2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpene which can be extracted from jujube plants. 2-O-trans-P-Coumaroyl alphitolic acid is a selective modulator of glucocorticoid receptor (GR). 2-O-trans-P-coumaroyl alphitolic acid can be used in the study of obesity.
    2-O-trans-p-Coumaroylalphitolic acid
  • HY-N12761
    Penpaxilloids A 98%
    Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity.
    Penpaxilloids A
  • HY-N12836
    Peniditerpenoid A 2982771-74-2 98%
    Peniditerpenoid A is a di-seco-indole diterpenoid. Peniditerpenoid A decreases the expression of p-IkBαby RANKL induced. Peniditerpenoid A inhibits RANKL induced osteoclast differentiation. Peniditerpenoid A has the potential for the research of osteoporosis.
    Peniditerpenoid A
  • HY-N12840
    Logmalicid B 1638895-74-5 98%
    Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research.
    Logmalicid B
  • HY-N12999
    Stigmast-5-en-3-ol 5779-62-4
    Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity.
    Stigmast-5-en-3-ol
  • HY-N13082
    Deacetylescin Ia 254896-53-2 98%
    Deacetylescin Ia (compound 12) is a deacetylated compound with anti-hyperglycemic effects that can be extracted from the debittered Aesculus and deacetylated at the C-22 position. Deacetylescin Ia (100 mg/kg) can inhibit blood glucose elevation in mouse glucose tolerance tests.
    Deacetylescin Ia
  • HY-N13137
    Timosaponin N 1010804-67-7 98%
    Timosaponin N is a natural steroidal saponin that inhibits the activity of α-Glucosidase. Timosaponin N can be used in diabetes-related research.
    Timosaponin N
  • HY-N13144
    Entagenic acid 5951-41-7 98%
    Entagenic acid, a glycoside ligand, can be derived from Entada phaseoloides seeds. Entagenic acid is used in anti-diabetic research.
    Entagenic acid
  • HY-N13173
    α-Glucosidase-IN-70 136832-00-3 98%
    α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC50=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes.
    α-Glucosidase-IN-70
  • HY-N13199
    3-O-Dihydro-p-coumaroyltohogenol 98%
    3-O-Dihydro-p-coumaroyltohogenol is a PTP1B inhibitor (IC50=6.27 μM) with antidiabetic and antiobesity activities.
    3-O-Dihydro-p-coumaroyltohogenol
  • HY-N13214
    Maca Extract (10:1) 98%
    Maca Extract is a maca extract. Maca Extract has the potential to improve fertility and sexual function, and can improve non-obstructive azoospermia. The polysaccharide part is its active ingredient. Maca Extract can alleviate seminiferous tubule vacuolation and testicular lesions. It improves sperm quantity and quality by promoting the recovery of seminiferous epithelium, inhibiting stromal cell proliferation, and increasing serum testosterone levels..
    Maca Extract (10:1)
Cat. No. Product Name / Synonyms Application Reactivity